Thymic Neuroendocrine Carcinomas With Combined Features Ranging From Well-Differentiated (Carcinoid) to Small Cell Carcinoma

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Thymic neuroendocrine carcinomas with combined features ranging from well-differentiated (carcinoid) to small cell carcinoma. A clinicopathologic and immunohistochemical study of 11 cases.

We reviewed 11 cases of primary thymic neuroendocrine carcinomas with combined features ranging from well-differentiated to poorly differentiated neuroendocrine carcinoma. For 3 asymptomatic patients, tumors were discovered during routine examination. Presentation in the other patients was as follows: Cushing syndrome, 2 patients; chest pain, 3 patients; superior vena cava syndrome, 1 patient; ...

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Thymic carcinoid tumor combined with thymoma--neuroendocrine differentiation in thymoma?

A carcinoid tumor of the thymus combined with thymoma in a 62-year-old man is described. The mediastinal tumor had been present for 13 years and was associated with pure red cell aplasia. Carcinoid tumor occupied the central two-thirds of the tumor, consisting of nests and trabeculae of monotonous round cells, which ultrastructurally showed many intracytoplasmic dense-core granules. Typical spi...

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Well-differentiated thymic carcinoma: is it thymic carcinoma or not?

We read the article titled “Thymic Carcinoma: Current Staging Does Not Predict Prognosis” by Blumberg and associates of Sloan-Kettering Cancer Center (J Thorac Cardiovasc Surg 1998;115:303-9). Thymic carcinomas in this article consisted of type II malignant thymoma 1 and well-differentiated thymic carcinoma. 2 Our Nagoya City University series of thymic carcinoma consisted of 19 patients treate...

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Well-Differentiated Neuroendocrine Tumors with a Morphologically Apparent High-Grade Component: A Pathway Distinct from Poorly Differentiated Neuroendocrine Carcinomas.

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Two cases of primary neuroendocrine carcinoma (carcinoid tumor) arising in the walls of a multilocular thymic cyst (MTC) are described. The patients were 2 men, ages 36 and 44 years. Clinically, the patients had chest pain, cough, and dyspnea. Radiographic evaluation demonstrated the presence of anterior mediastinal tumor in both patients, and complete surgical resection of the tumor mass was p...

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ژورنال

عنوان ژورنال: American Journal of Clinical Pathology

سال: 2000

ISSN: 1943-7722,0002-9173

DOI: 10.1309/q01u-60bl-vev4-twr1